1Experimental
Neuroimaging Laboraory, Department of Neurology and Biomedical Research
Imaging Center, University of North Carolina, Chapel Hill, NC, United States;
2Department of Radiology, University of North Carolina, Chapel
Hill, NC, United States
This study demonstrates unexpected BOLD fMRI response in the motor cortex as a result of DBS at the STN. This response is frequency dependent, peaking at 100 Hz with increased glucose metabolism as confirmed by FDG-microPET. This pattern of frequency-dependence suggests a relationship to the therapeutic effect of STN DBS for Parkinsons disease which may be further investigated by the use of this technique in parkinsonian animal models.