Abstract #0062
Regional Metabolism During Healthy Aging in Mice Brain: A 1 H-[ 13 C]-NMR Study
Anant Bahadur Patel 1 , Pandichelvam Veeraiah 1 , Mohammad Shamim 1 , and M Jerald Mahesh Kumar 1
1
NMR Microimaging and Spectroscopy, CSIR-Centre
for Cellular and Molecular Biology, Hyderabad, Andhra
Pradesh, India
Despite key role of neurotransmitters in brain function,
brain energy metabolism has not been explored during
healthy aging. In this study, we have investigated
neuronal and astroglial metabolism in the cerebral
cortex, hippocampus and striatum of adult and aged
C57BL6 mice by using
1
H-[
13
C]-NMR
spectroscopy together with infusion of
13
C
labeled substrates. The
13
C
turnover of amino acids was analyzed using a three
compartment metabolic model to derive the metabolic
rates. Aging is associated with an increased in
astroglial flux and decrease in glutamatergic and
GABAergic rates across different brain regions.
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