Abstract #0072
High resolution HARDI of early embryonic mouse brain development
Dan Wu 1 , Ilan Gobius 2 , Linda J Richards 2 , Susumu Mori 3 , and Jiangyang Zhang 3
1
Biomedical Engineering, Johns Hopkins
University School of Medicine, Baltimore, Maryland,
United States,
2
Queensland
brain Institute, The University of Queensland, Brisbane,
Queensland, Australia,
3
Radiology,
Johns Hopkins University School of Medicine, Baltimore,
Maryland, United States
Diffusion MRI is an ideal tool to characterize the
microstructures in the embryonic mouse brain, and high
resolution is key to delineate these fine structures.
Using a 3D diffusion-weighted gradient and spin echo
sequence, we were able to acquire HARDI data of the
embryonic mouse brains at 30 to 45 m isotropic
resolution and 30 diffusion directions. The
high-resolution data from embryonic day 10.5 (E10.5) to
E15.5 (n=5 per stage) revealed the dynamic changes in
the early gray and white matter structures with
unprecedented details.
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