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Abstract #0098

Diffusion MRI with q-vector magic angle spinning (qMAS) disentangles effects of micro-anisotropy and orientation dispersion

Filip Szczepankiewicz 1 , Samo Lasic 2 , Jimmy Ltt 3 , Danielle van Westen 4 , Carl-Fredrik Westin 5 , Freddy Sthlberg 1,4 , Daniel Topgaard 6 , and Markus Nilsson 7

1 Department of Medical Radiation Physics, Lund University, Lund, Sweden, 2 CR Development, AB, Lund, Sweden, 3 Center for Medical Imaging and Physiology, Skane University Hospital, Lund, Sweden, 4 Department of Diagnostic Radiology, Skane University Hospital, Lund, Sweden, 5 Laboratory of Mathematics in Imaging, Harvard Medical School, Boston, MA, United States, 6 Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden, 7 Lund University Bioimaging Center, Lund University, Lund, Sweden

In this work we present the first in vivo experiments employing magic angle spinning of the q-vector (qMAS) to map the microscopic anisotropy of the brain. This technique allows for the parameterization of anisotropy that is unaffected by the orientation dispersion. This means that the anisotropy is probed on a sub-voxel scale, and can potentially be useful in complex white matter geometries and gray matter, where conventional metrics such as FA are confounded by the tissue micro architecture.

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