GABAergic effect on resting-state functional connectivity
Fatima Nasrallah 1 , Kavita Kaur D/O Ranjit Singh 2 , Yeow Ling Yun 2 , and Kai-Hsiang Chuang 2
Clinical Imaging Research Center, Singapore,
Bioimaging Consortium, Singapore, Singapore, Singapore
To understand the neurotransmission basis of
resting-state functional connectivity, BOLD and EEG were
measured when GABAA receptor system was antagonized by
bicuculline. We found that inhibition of the GABAergic
system in the brain increases both neural activity and
functional connectivity. EEG shows intact neurovascular
coupling and increased beta and gamma oscillation at
resting state. This supports the neural basis and the
role of inhibitory system on functional connectivity.
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