Assessment of cholinergic synaptic transmission modulation in the mouse brain using resting-state functional Magnetic Resonance Imaging (rsfMRI)
Disha Shah 1 , Rafael Delgado y Palacios 1 , Pieter-Jan Guns 1 , Elisabeth Jonckers 1 , Marleen Verhoye 1 , and Annemie Van der Linden 1
University of Antwerp, Bio-Imaging Lab,
Wilrijk, Antwerp, Belgium
We hypothesize that synaptic transmission deficits in
neurodegenerative disorders (ND) could be reflected as
altered brain functional connectivity (FC) and can be
detected using resting-state fMRI (rsfMRI). We
investigate this hypothesis by pharmacologically
modulating cholinergic synaptic transmission in the
mouse brain using scopolamine and milameline.
Scopolamine induced a decrease of FC between the
hippocampus and thalamus and the hippocampus
bilaterally, connections involved in learning/memory.
The scopolamine-induced FC deficits are reversed by
milameline. These results have implications for studies
in animal models of ND, where rsfMRI can be used as a
non-invasive tool to detect the modulation of synaptic
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