Age-related changes of the bound pool fraction in white matter
Lukas Pirpamer 1 , Florian Franz Erich Borsodi 1 , Gernot Reishofer 2 , Christian Langkammer 1 , Reinhold Schmidt 1 , and Stefan Ropele 1
Department of Neurology, Medical University
of Graz, Graz, Austria,
of Radiology, Medical University of Graz, Graz, Austria
The bound pool fraction (BPF) is a fundamental parameter
for magnetization transfer and therefore expected to be
more sensitive for age-related tissue changes compared
to the conventional MTR. This study investigated the
change of the BPF in several white-matter regions
assessed over age in a normal aging cohort. This study
confirms the higher sensitivity of the BPF in particular
for WM regions that are susceptible for developing age
related white matter hyperintensities.
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