Multi-parametric MRI characterization of methylene blue treatment of mild Traumatic Brain Injury
Lora Talley Watts 1 , Justin Alexander Long 1 , Jonathan Chemello 1 , Qiang Shen 1 , Shiliang Huang 1 , and Timothy Duong 1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
Texas, United States
This study investigated the spatiotemporal dynamics of
diffusion, T2 and fractional anisotropy associated with
mild traumatic brain injury (TBI) following methylene
blue treatment. Lesion volume, diffusion, T2 and
fractional anisotropy changes and behavioral scores
generally correlated well with the improvement by
methylene blue treatment compared to placebo controls.
However, despite the presence of some lesions on day 7
and 14, behavioral measures mostly returned to normal in
both groups, suggesting that there is functional
compensation in our mild TBI model. Multi-parametric MRI
offers a range of biomarkers that are sensitive to
different tissue types and to different stages of TBI.
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