Abstract #0344
T 1 Measurement of the Myelin Water Fraction
Peter van Gelderen 1 , Xu Jiang 1 , Jacco A de Zwart 1 , and Jeff H Duyn 1
1
AMRI, LFMI, NINDS, National Institutes of
Health, Bethesda, MD, United States
To investigate the possibility of using T
1
contrast
to selectively image myelin water, inversion-recovery
prepared multi-gradient-echo imaging was performed on
human subjects at 7T. Multi-component fitting of the T
2
*
decay curve allowed distinguishing between water inside
and outside the myelin sheath and quantifying individual
T
1
-decay time constants. When properly
accounting for imperfect inversion efficiency, no
substantial difference between apparent T
1
of
the different compartments was found, suggesting a
relatively rapid exchange of water within and outside
the myelin sheath.
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