Abstract #0473
Generation of Multicolor/multiparametric MRI-CEST maps of murine tumor by using YbHPDO3A and Dy-loaded Red Blood Cells.
Giuseppe Ferrauto 1 , Enza Di Gregorio 1 , Daniela Delli Castelli 1 , Enzo Terreno 1 , and Silvio Aime 1
1
Molecular Biotechnologies & Health Sciences,
Molecular Imaging Center, Torino, Italy
Three key hallmarks of the tumor development are
represented by the increased vascular volume, the
enhanced vascular permeability and the acidification of
the extracellular/extravascular pH (pHe). CEST contrast
agents appear well suitable to visualize simultaneously
the three biomarkers by using the currently available
1H-MRI scanners. YbHPDO3A, a small hydrophilic, well
tolerated paraCEST agent, chemical analogue of the
clinically approved ProHance, provides the way to get
information both on change in pHe and on change in
vascular permeability. Semi-quantitative information on
the vascular volume have been obtained by using
Dysprosium- loaded Red Blood Cells, a new kind of CEST
contrast agent.
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