In vivo T 2 * effect on pharmacokinetic parameter estimation using reference tissue arterial input function at 7T
Jin Zhang 1 , Melanie Freed 1 , Kerryanne Winters 1 , and Sungheon Kim 1
Radiology, New York University, New York,
New York, United States
The influence of T
lesion signal intensity and arterial input function at
high field can induce systemic errors in pharmacokinetic
parameter estimation. When the arterial input function
is estimated from reference tissue, the T
on parameter estimation may be relatively smaller than
when it is directly measured. In this study, we
investigate the influence of a Gd-based contrast agent
on the T
tumor at 7T and its effect on kinetic model analysis.
Our preliminary results show no significant difference
between pharmacokinetic model parameters from T
and non-corrected data when a reference tissue arterial
input function is used.
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