A Multimodal Approach for Comprehensive Segmentation of the Substantia Nigra
Jason Langley 1 , Daniel Huddleston 2,3 , Xiangchuan Chen 1 , Jan Sedlacik 4 , Shiyang Chen 1 , and Xiaoping Hu 1
Wallace H. Coulter Department of Biomedical
Engineering, Georgia Institute of Technology and Emory
University, Atlanta, GA, United States,
of Neurology, Emory University, Atlanta, GA, United
for Health Research, Southeast, Kaiser Permanente,
Atlanta, GA, United States,
of Neuroradiology, University Medical Center Hamburg-Eppendorf
(UKE), Hamburg, Germany
Degeneration of the substantia niagra(SN) is a hallmark
of many neurodegenerative disorders including
Parkinsons disease and Alzheimers disease.
Visualization and volumetric quantification of the SN
would be beneficial to early detection of both diseases.
Magnetization transfer contrast (MTC) imaging is
sensitive to neuromelanin-containing structures in the
brain and susceptibility weighted imaging (SWI) is
sensitive to iron. This abstract compares the
segmentation results of the SN from MTC and SWI images.
Both methods give volumetric estimates that are
approximately similar but the spatial overlap between
the two regimes is ~11%. Indicating a multimodal
approach will yield more accurate segmentation results.
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