Abstract #0574
Hippocampal Intravoxel Incoherent Motion Imaging in Type 2 Diabetes Mellitus and memory impairment
Frank C.G. van Bussel 1 , Walter H. Backes 1 , Paul A.M. Hofman 1 , Alfons G.H. Kessels 2 , Tamar M. van Veenendaal 1 , Harm J. van de Haar 1 , Martin P.J. van Boxtel 3 , Miranda T. Schram 4 , Coen D.A. Stehouwer 4 , Joachim E. Wildberger 1 , and Jacobus F.A. Jansen 1
1
Radiology, Maastricht University Medical
Center, Maastricht, Netherlands,
2
Clinical
Epidemiology and Medical Technology Assessment,
Maastricht University Medical Center, Maastricht,
Netherlands,
3
Psychiatry
and Neuropsychology, Maastricht University Medical
Center, Maastricht, Netherlands,
4
Internal
Medicine, Maastricht University Medical Center,
Maastricht, Netherlands
Type 2 Diabetes Mellitus (T2DM) is associated with
cognitive decline. A prominently affected cognitive
domain is memory, for which the hippocampus is
essential. Blood glucose levels can affect hippocampal
microstructure and memory performance. IVIM metrics
(diffusion coefficient (D) and perfusion fraction (f))
might be a good candidate as MRI biomarkers for memory
decline in T2DM. This study showed that in the left
hippocampus, a high D was associated with lower memory
performance, and an association of f with increased
blood glucose levels. This suggests that hippocampal
microstructure is injured and a vascular component is
involved which might underlie memory problems.
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