Pseudo Extravasation Rate Constant of Dynamic Susceptibility Enhanced Magnetic Resonance Imaging Determined From Pharmacokinetic First Principles
Xin Li 1 , Csanad Varallyay 2 , Seymur Gahramonov 2 , William D Rooney 1 , and Edward A Neuwelt 2
Advanced Imaging Research Center, Oregon
Health & Science University, Portland, Oregon, United
of Neurology, Oregon Health & Science University,
Portland, Oregon, United States
Though widely adopted for brain perfusion measurement,
Dynamic Susceptibility Contrast (DSC) Magnetic Resonance
Imaging (MRI) with low molecular weight Gadolinium (Gd)
contrast reagent (CR) is often confounded by CRs
leakage into intersitium space. Based on pharmacokinetic
first principles, we demonstrate a fast leakage
correction method similar to that of the Patlak plot.
This linearization approach uniquely identifies the
leakage rate constant and significantly simplifies
relative cerebral blood volume (rCBV) quantification.
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