Abstract #0725
Simutaneous measurement of pharmacokinetic model parameters and T 1 /B 1 using Active Contrast Encoding MRI
Jin Zhang 1 and Sungheon Kim 1
1
Radiology, New York University, New York,
New York, United States
In DCE-MRI studies, accurate estimation of
pharmacokinetic model parameters requires B
1
-corrected
T
1
values.
However, it is not trivial to measure B
1
and T
1
accurately
in addition to the long scan time. In this study, we
proposed a novel approach, namely active contrast
encoding (ACE) MRI, to measure both B
1
and
T
1
values
along with kinetic parameters from a single DCE-MRI
data. A proof-of-concept study was conducted to
demonstrate the proposed method using numerical
simulations and an in vivo mouse study, and to show that
ACE-MRI can eliminate the need to have separate B
1
and
T
1
mapping procedures.
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