Detection of Acute Response to Proteasome Inhibitor Treatment in Mouse Colorectal Tumour Models Using Amide Proton Transfer (APT) Magnetic Resonance Imaging
Yanan Zhu 1 , Rajiv Ramasawmy 1 , Sean Peter Johnson 2 , Valerie Taylor 1 , Barbara Pedley 2 , Allison Berger 3 , Nibedita Chattopadhyay 3 , Daniel Bradley 4 , Mark Lythgoe 1 , and Simon Walker-Samuel 1
UCL Centre for Advanced Biomedical Imaging,
University College London, London, Greater London,
Cancer Institute, University College London, Greater
London, United Kingdom,
Pharmacology Takeda Pharmaceutical International
Corporation, MA, United States,
Biomedical Imaging Group, Takeda Pharmaceutical
International Corporation, MA, United States
In this study, amide proton transfer (APT) imaging was
used to assess the acute response of a colorectal
xenograft model to proteosome inhibitor therapy (ixazomib).
Tumour apparent diffusion coefficient (ADC), T1, and T2
were also acquired, alongside 31P magnetic resonance
spectroscopy data. Treated mice showed an inhibited
tumour growth rate, decreased APT and increased ADC,
compared with control mice, which could be due to
changes in protein homeostasis as a result of proteasome
inhibition by the drug.
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