CEST-MRI detects metabolite levels for monitoring breast cancer cell aggressiveness
Kannie WY Chan 1,2 , Lu Jiang 3 , Jannie P Wijnen 3 , Guanshu Liu 1,2 , Tiffany Greenwood 1 , Menglin Chen 1 , Peter CM van Zijl 1,2 , Michael T McMahon 1,2 , and Kristine Glunde 3,4
Radiology, Johns Hopkins University School
of Medicine, Baltimore, MD, United States,
Krieger Institute, Baltimore, MD, United States,
Division of Cancer Imaging Research, Johns Hopkins
University School of Medicine, Baltimore, MD, United
Kimmel Comprehensive Cancer Center, MD, United States
Altered metabolism is a hallmark of cancer, and in vivo
assessment of metabolite levels is important for cancer
diagnosis, development of anti-cancer treatments, and
treatment monitoring. In the in vivo setting, MR
spectroscopic imaging (MRSI) is not able to spatially
resolve some of the metabolites that are important in
cancer due to their relatively low concentrations.
Chemical Exchange Saturation Transfer (CEST) is a
molecular imaging approach that can improve detection
sensitivity. Here we applied CEST to detect exchangeable
protons of common cellular metabolites, showing that the
metabolite CEST contrast in breast cell lines is
inversely correlated with cancer cell aggressiveness.
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