Diastolic Dysfunction is Closely Associated with Myocardial Steatosis in Women at Risk for Heart Failure with Preserved Ejection Fraction
Lidia S. Szczepaniak 1 , Janet Wei 1 , Michael D. Nelson 1 , Laura G. Smith 1 , Edward W. Szczepaniak 1 , Louise Thomson 1 , Daniel Berman 1 , Debiao Li 1 , and C. Noel Bairey Merz 1
Cedars-Sinai Medical Center, Los Angeles,
California, United States
Impaired left ventricular (LV) filling is an important
manifestation of heart failure with preserved LV
ejection fraction (HFpEF), and is regarded as a primary
contributor to morbidity and mortality in this
population. Despite our general understanding, however,
the exact mechanism for diastolic dysfunction remains
unclear. Myocardial fat accumulation is associated with
diastolic dysfunction in other disease states and thus
may play an important role in the pathogenesis of HFpEF.
We directly address this hypothesis by evaluating
myocardial triglyceride content and diastolic function
in a patient population at increased risk for HFpEF.
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