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Abstract #1136

Selective acidification and de-energization of A2780 ovarian cancer xenografts using lonidamine: A preliminary 1H and 31P MRS study

Kavindra Nath 1 , Ting Liu 1 , David S Nelson 1 , Daniel F Heitjan 1 , Dennis B Leeper 2 , Jerry D Glickson 1 , I-Wei Chen 1 , and Rong Zhou 1

1 University of Pennsylvania, Philadelphia, Pennsylvania, United States, 2 Thomas Jefferson University, Philadelphia, Pennsylvania, United States

In vivo 31P Magnetic Resonance Spectroscopy demonstrates that A2780 ovarian cancer xenografts treated with the monocarboxylate transporter-1 (MCT-1) inhibitor, lonidamine (LND), exhibits a sustained and tumor-selective decrease in delta pHi and pHe of 0.56 0.10 (p < 0.05) and 0.34 0.23 (p = 0.05) respectively. Tumor bioenergetics (╬▓NTP/Pi) decreased by 70.0 22% (p < 0.05) and integrated intensities of the steady-state tumor lactate were increased after 40 min. (p < 0.05) relative to the baseline level following LND administration. The decline of pHi and bioenergetics could be critical parameters for chemo- and thermo-sensitization of ovarian cancers.

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