Abstract #1138
Dynamic MRS of hyperpolarized 1- 13 C pyruvate in brain tumor afflicted mice treated with temozolomide
Teresa Delgado-Goi 1,2 , Eva Monteagudo 3 , Miquel E. Cabaas 3 , Carles Ars 1,2 , and Silvia Lope-Piedrafita 3
1
Department de Bioqumica i Biologia
Molecular, Unitat de Bioqumica de Biocincies,
Universitat Autnoma de Barcelona, Cerdanyola del Valls,
Barcelona, Spain,
2
Centro
de Investigacin Biomdica en Red en Bioingeniera,
Biomateriales y Nanomedicina (CIBER-BBN), Cerdanyola del
Valls, Barcelona, Spain,
3
Servei
de RMN, Universitat Autnoma de Barcelona, Cerdanyola
del Valls, Barcelona, Spain
In this study we aimed to evaluate the detection of
response to temozolomide therapy in a well characterized
mouse brain glioma model by hyperpolarized [1-13C]
pyruvate. Quantification of time course 13C spectra
showed significant differences between wildtype and
untreated-glioblastoma-bearing mice in the lactate
signals from 12s to 50s post-injection. However no
differences were observed in lactate between untreated
and treated glioblastoma-bearing mice. Nevertheless,
individual Lac/Pyr ratios of treated mice seemed to have
two separate patterns, one with increased ratios and the
other with smaller values, which could indicate
different behavior with respect to therapy response
variability in the evaluated mice.
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