White matter abnormalities in mesocorticolimbic network of drug nave ADHD children by diffusion tensor imaging
Lizhou Chen 1 , Xinyu Hu 1 , Qi Liu 1 , Yi Liao 1 , Ning He 2 , Fei Li 1 , Ying Chen 2 , Lanting Guo 2 , Qiyong Gong 1 , and Xiaoqi Huang 1
Huaxi MR Research Center(HMRRC), West China
Hospital of Sichuan University, Chengdu, Sichuan, China,
of Psychiatry, West China Hospital of Sichuan
University, Chengdu, Sichuan, China
White matter (WM) abnormality had been studied with
diffusion tensor imaging with inconsistent results while
underline mechanism remained unclear. Present study
performed in-depth investigation into WM abnormalities
in a relatively large sample of ADHD children by using
multiple diffusion parameters, including fractional
anisotropy (FA), radial diffusivity and axial
diffusivity. The relationship between FA and
neuropsychiatric measurements was also explored.
Increased FA with discrepant cellular alternating
patterns was detected in left cingulate bundle and
posterior-body of corpus callosum, and the alternation
of FA correlated with some cognitive domains.
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