Verbal Memory Function, Glutamate, and Cerebral Blood Flow in Older Adults with Schizophrenia
S. Andrea Wijtenburg 1 , Benjamin W Krause 1 , Frank Gaston 1 , Stephanie Korenic 1 , Sarah Nisonger 1 , Peter Kochunov 1 , Danny JJ Wang 2 , L Elliot Hong 1 , and Laura M Rowland 1,3
MPRC, University of Maryland School of
Medicine, Baltimore, MD, United States,
University of California Los Angeles, CA, United States,
H. Morgan Department of Radiology and Radiological
Science, Johns Hopkins University School of Medicine,
Baltimore, MD, United States
Older adults with schizophrenia (SZ) have significant
memory impairments when compared to healthy age-matched
controls, and the pathophysiology of these memory
impairments is poorly understood. Assessments of
declarative verbal memory, glutamate, and regional
cerebral blood flow from brain regions associated with
verbal memory function (hippocampus and anterior
cingulate) were conducted in older adults. Data were
acquired on a 3T scanner from stable, chronic younger
and older adults with SZ and age-matched controls.
Results showed lower glutamate, CBF, and verbal memory
scores in older adults with SZ.
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