Abstract #1995
Decreased Interhemispheric Functional Connectivity in first-episode drug-nave Major Depressive Disorder
Hong Yang 1 , Zhan Feng 1 , Shunliang Xu 1 , and Manli Huang 2
1
Department of Radiology, First Affiliated
Hospital of College of Medical Science, Zhejiang
University, Hangzhou, Zhejiang, China,
2
Department
of psychiatry, First Affiliated Hospital of College of
Medical Science, Zhejiang University, Hangzhou,
Zhejiang, China
The resting state functional connectivity were examined
between the two hemispheres in MDD patients using a
recently proposed measurement named voxel-mirrored
homotopic connectivity (VMHC). Twenty-three
first-episode, medication-naive patients were compared
with twenty matched controls. Compared to the controls,
the MDD patients showed significant decreased VMHC in:
superior frontal gyrus, middle frontal gyrus, inferior
frontal gyrus, hippocampus, parahippocampa gyrus, middle
temporal gyrus, insula, putamen, caudate, parietal lobe,
middle occipital gurus and precuneus. These findings
suggest that the functional coordination between
homotopic brain regions is impaired in MDD patients.
Furthermore these impaired long-range connections likely
reflect failure functional networks integration process
in MDD.
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