Prospective study of changes in regional brain myelin content after concussion
Elham Shahinfard 1 , Michael Jarrett 1 , Irene Vavasour 1 , Shannon Kolind 1 , Enedino Hernndez-Torres 1 , Jack Taunton 1 , David K Li 1 , and Alexander Rauscher 1
University of British Columbia, Vancouver,
Repetitive concussion or hits to the head can have
serious cumulative effects. Studies in animals and in
humans with moderate to severe traumatic brain injury
suggest damage to the axon's myelin sheath. We studied
two ice hockey teams over one season and measured the
brain's myelin water fraction before and after
concussion. Voxel-wise tract based statistical analysis
showed significant reduction of myelin water fraction at
two weeks post-injury for the eleven concussed subjects.
Using an atlas-based based region of interest approach,
we found reduction in myelin in the whole cohort at the
end of the hockey season compared to baseline.
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