Tissue outcome in areas surrounding the impact site in traumatic brain injury
Justin Alexander Long 1 , Lora Talley Watts 1 , Qiang Shen 1 , Shiliang Huang 1 , and Timothy Duong 1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
Texas, United States
We previously reported heterogeneous perfusion
disruption beyond the impact area following mild TBI.
However, it is unclear how such hemodynamic disruption
affects tissue outcome. This study evaluated the effects
of perfusion deficit on ADC, T2 and FA by analyzing a
series of ROIs away from to the impact area. MRI
parameters did not changed when CBF dropped to 60% of
normal, but changed only when CBF dropped below 20% of
normal at 1-3hrs and 2 days post TBI. CBF recovered on
day 14 and so did FA, ADC and T2 values, suggesting that
this mild TBI model induces reversible injury.
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