BBB Breakdown due to Axonal Degeneration: A Potential Confounding Factor for MS Diagnosis
Shu-Wei Sun 1,2 , Christopher Nishioka 3 , Steven Kaspick 4 , Chen-Fang Chung 4 , JoAnn Park 4 , and Hsiao-Fang Liang 4
Loma Linda University, Loma Linda, CA,
of California, Riverside, Riverside, CA, United States,
of California, Riverside, CA, United States,
Linda University, CA, United States
Retina ischemia caused axonal degeneration along optic
nerve (ON) and tract (OT) of WldS and wild-type, while
the damage was delayed in WldS. In WldS, ON and OT
showed significant reductions of axial diffusivity in
weeks 1 and 2, respectively, which provided us the time
window of distinguished injure severity between the
proximal (ON) and distal sections (OT) of RGC axons.
Gd-T1WI and Evans blue both showed significant BBB
leakage in RI-affected ON and OT beginning at week 1 in
WldS mice. The remote BBB leakage may be observed in
Gd-T1WI and may confuse the MS diagnosis.
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