Characterizing the microstructural and architectural organization of healthy kidney tissue using diffusion tensor imaging, fiber tractography and intra-voxel incoherent motion.
Sophie van Baalen 1 , Alexander Leemans 2 , Pieter Dik 1 , Bennie ten Haken 3 , and Martijn Froeling 2
Pediatric Urology, University Medical Centre
Utrecht/ WKZ, Utrecht, Netherlands,
science institute, University Medical Centre Utrecht,
Biomedical Technology and Technical Medicine, University
of Twente, Enschede, Netherlands
For imaging of kidney pathologies, the use of endogenous
contrast is important, because contrast agents can
further damage renal function. MRI-DTI and IVIM are
promising imaging techniques for kidney imaging because
they enable to measure the extent and direction of water
diffusion and the perfusion fraction, respectively. In
this study we used MRI-DTI and IVIM to visualize the
microstructural properties of kidney tissues. With
MRI-DTI and tractography, the radially orientation of
the tubules and vascular network in the renal medulla is
reflected by radially oriented tracts, originating in
the cortex and convolving in multiple papillae. With
IVIM, blood perfusion and urine diffusion fractions can
be visualized for different kidney tissues.
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