Imaging of Structural and Functional Changes in Early Stage CF with 3 He MRI, 1 H MRI and CT
Helen Marshall 1 , David Hughes 2 , Felix Horn 1 , Juan Parra-Robles 1 , Alex Horsley 3 , Laurie Smith 2 , Leanne Armstrong 1 , Ina Aldag 2 , Chris Taylor 2 , and Jim M Wild 1
Academic Radiology, University of Sheffield,
Sheffield, United Kingdom,
Children's Hospital, Sheffield, United Kingdom,
Adult CF Centre, University of Manchester, Manchester,
Early detection of lung disease is vital for effective
treatment of cystic fibrosis. This study investigated
the relative sensitivity of
anatomical MRI and CT for detection of early stage lung
disease in children with mild CF. 7 CF patients with
normal spirometry and 5 healthy controls were studied.
Abnormalities were detected in the
MR and CT images of 6 patients, and the
MR images of 3 patients.
MRI and CT provide complementary information about lung
structure and function, and are more sensitive to early
ventilation changes than
MRI in mild CF.
This abstract and the presentation materials are available to members only;
a login is required.