Comprehensive structure/function MRI of cystic fibrosis
Scott K Nagle 1,2 , Laura C Bell 2 , Christopher J Francois 1 , Robert V Cadman 2 , Stanley J Kruger 2 , Andrew D Hahn 2 , and Sean B Fain 1,2
Radiology, University of Wisconsin, Madison,
WI, United States,
Physics, University of Wisconsin, Madison, WI, United
MRI has significant potential advantages over CT for
longitudinal surveillance of cystic fibrosis (CF) with
respect to reduced radiation dose, ability to image
regional function, and the potential for earlier
detection of disease progression or treatment response.
In this study, the performance of several MRI methods
for the detection of cystic fibrosis (CF) lung disease
were evaluated in comparison to CT reference standards.
MRI included both functional (3He ventilation and
dynamic contrast-enhanced perfusion) and
anatomic/structural methods, including a 3D radial
ultrashort echo time (UTE) approach. There were strong
correlations between CT air trapping and He-3 MRI,
perfusion MRI, and UTE MRI.
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