Wall shear stress quantification and reproducibility using variable VENC 4D phase contrast MRI in the aorta
Wouter V Potters 1 , Anders Nilsson 2 , Sandra van den Berg 1 , Ed vanBavel 3 , Karin Markenroth Bloch 4 , Freddy Sthlberg 2,5 , and Aart J Nederveen 1
Radiology, Academic Medical Center,
Radiation Physics, Lund University, Lund, Sweden,
Engineering & Physics, Academic Medical Center,
Healthcare, Lund, Sweden,
Radiology, Lund University, Lund, Sweden
Wall shear stress (WSS) is the force exerted by the
flowing blood on the endothelial cells. WSS has been
correlated with endothelial function and wall thickness.
Quantification of WSS from 4D phase contrast MRI (4DPC)
can be performed in the aorta, but is challenging in the
diastolic part of the heart cycle due to a low velocity
to noise ratio (VNR). A variable VENC 4D PC-MRI (4DvPC)
sequence can significantly improve the VNR in diastole.
We compared WSS quantification between 4DPC and 4DvPC to
see if the improved VNR will also improve the diastolic
WSS quantification. Additionally we investigated the WSS
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