Abstract #2474
Identifying regions of abnormal wall shear stress in patients with bicuspid aortic valves
Pim van Ooij 1 , Maria Carr 1 , Bradley D. Allen 1 , David G. Guzzardi 2 , Jeremy Collins 1 , James Carr 1 , S. Chris Malaisrie 3 , Paul W. M. Fedak 2 , Patrick McCarthy 4 , Michael Markl 1,5 , and Alex J. Barker 1
1
Radiology, Northwestern University, Chicago,
IL, United States,
2
Cardiac
Surgery, University of Calgary, Calgary, Alberta,
Canada,
3
Medicine-Cardiology,
Northwestern University, Chicago, IL, United States,
4
Surgery-Cardiac
Surgery, Northwestern University, Chicago, IL, United
States,
5
Biomedical
Engineering, Northwestern University, Chicago, IL,
United States
In this study, a methodology is presented that enables
identification of abnormal WSS, estimated by 4D flow
MRI, in patients with bicuspid aortic valve (BAV) by
comparison with a cohort-averaged 3D WSS map of healthy
controls. 11 BAV patients were compared with a
mean1.96*standard deviation WSS map created from data
of 10 controls. In the BAV patients, elevated WSS was
predominantly found in the inner (8%) and outer
ascending aorta surface (21%) and outer arch surface
(16%). Moderate correlations were found between the
significant surface area and aortic diameter (R2 of 0.8,
0.5 and 0.4, respectively).
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