Whole-brain distortion-free pseudo-continuous arterial spin labeling using multiband turbo-FLASH at 3 and 7T
Yi Wang 1 , Steen Moeller 2 , An T. Vu 2 , Kamil Ugurbil 2 , Essa Yacoub 2 , and Danny JJ Wang 1
Neurology, UCLA, Los Angeles, CA, United
of Magnetic Resonance Research, University of Minnesota,
MN, United States
Multiband imaging or simultaneous multi-slice excitation
has recently been applied for arterial spin labeling
perfusion MRI using Blipped-CAIPI based EPI readout. It
has been shown that this technique can expedite ASL
imaging acquisition, improve image coverage and/or
resolution with little penalty or even gain in SNR.
Another advantage of MB acquisition for ASL is shortened
T1 relaxation of the label, which degrades ASL signal in
conventional sequential 2D EPI readout. However, MB EPI
still suffers from susceptibility, N/2 ghosting and
other distortion artifacts, especially at high and
ultrahigh magnetic fields. In this work, we present a MB
turbo-FLASH based pseudo-continuous ASL sequence that is
able to provide whole-brain distortion-free perfusion
images at both 3 and 7T.
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