Arterial spin labelling characterization of cerebral perfusion during normal maturation from late childhood into adulthood: normal reference range values
Patrick W Hales 1 , Jamie M Kawadler 1 , Sarah E Aylett 2 , Fenella J Kirkham 3 , and Christopher A Clark 1
Imaging & Biophysics Unit, Institute of
Child Health, University College London, London, United
Ormond Street Hospital, London, United Kingdom,
Unit, Institute of Child Health, Univsersity College
London, London, United Kingdom
We used arterial spin labelling MRI to measure changes
in cerebral haemodynamics during normal development,
between 8-32 years of age. We present mean and normal
reference ranges for T1, M0 (equilibrium longitudinal
magnetization), cerebral blood flow (CBF), bolus arrival
time and bolus duration. A negative correlation with age
was seen in CBF and T1 throughout cortical grey matter.
Increased bolus dispersion with age was observed in the
anterior and posterior arterial territories, and gender
differences were seen in the evolution of M0. These data
will help when optimizing ASL protocols for paediatric
imaging, and identifying age-matched perfusion
abnormalities in pathologies.
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