Detection of Hyperpolarized [5-13C]-Glutamine in Brain
Concetta Valeria Gringeri 1,2 , Eugen Kubala 1,2 , Ulrich Koellisch 2,3 , Annette FranK 1 , Rolf Schulte 2 , Axel Haase 3 , Markus Schwaiger 1 , Steffen Glaser 4 , and Marion Irene Menzel 2
Institute of Nuclear Medicine, Klinikum
rechts der Isar, TUM, Munich, Bayern, Germany,
Global Research, Munich, Bayern, Germany,
TUM, Munich, Bayern, Germany,
of Chemistry, TUM, Munich, Bayern, Germany
A change in neurotransmitter levels (glutamate,
glutamine and GABA) was demonstrated recently in the
striatum at Parkinsons disease models using 1H MRS.
Glutamine is able to cross the BBB by facilitated
diffusion, however compared to other neutral amino acids
this process is slower. Therefore brain distribution of
hyperpolarized [5-13C]-glutamine was imaged in Lewis
healthy rats. A sufficient glutamine signal was detected
in different brain areas. In the main future 13C-MRI
might provide novel and more selective tools to study
the transport systems and evaluate their regulation in
vivo. In this sense hyperpolarized glutamine can be
considered a promising candidate.
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