Survival from Brain Metastasis of Breast Cancer is Inversely Correlated with Hyperpolarized 1-13C Lactate/Pyruvate ratio: Preliminary Study in Nude Mouse Model.
Young-suk Choi 1 , Joon-Sung Lee 2,3 , Han-Sol Lee 3 , Hyun-Jin Park 1 , Ju-Hyun Lee 1 , Eun-Kyung Wang 1 , Seung-Wook Yang 3 , Eun-Hae Joe 3 , Dong-Hyun Kim 3 , and Ho-Taek Song 1
Department of Radiology, Yonsei University
College of Medicine, Seodaemun-Gu, Seoul, Korea,
Yonsei University College of Medicine, Seodaemun-Gu,
Department of Eletrical &
Electronic Engineering, Yonsei University, Seodaemun-Gu,
In brain metastasis from breast cancer mouse model, we
evaluate the pyruvate to lactate conversion ratio to
monitor the alteration of metabolism by metformin by
hyperpolarized 13C metabolic MRS imaging. The inhibition
of tumor growth by metformin was not proved by
conventional imaging and hyperpolarized 13C MRSI.
Individual conversion ratio of 13C pyruvate to 13C
lactate showed inverse correlation with survival
regardless of experimental group. Hyperpolarized 13C
MRSI may be useful tool to predict the prognosis cancer
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