Abstract #2848
Development of a surface-switching theranostic lipid-PLGA hybrid nanoparticle platform
Line Hansen 1,2 , Francois Fay 1 , Anita Gianella 1 , Pedro Ramos-Cabrer 1 , Bram Priem 1 , Brenda Sanchez 1 , Aneta J. Mieszawska 1 , Robert Langer 3 , Jrgen Kjems 2 , Zahi A. Fayad 1 , and Willem J. M. Mulder 1
1
Translational and Molecular Imaging
Institute at Icahn School of Medicine, Mount Sinai, New
York, NY, United States,
2
Interdisciplinary
Nanoscience Center (iNANO), Aarhus University, Aarhus C,
Denmark,
3
Department
of Chemical Engineering, Massachusetts Institute of
Technology, Cambridge, MA, United States
Surface-swtichable lipid/PLGA hybrid nanoparticles with
an MMP-2 cleavable PEG coating were developed. To enable
near infrared optical imaging and MRI, Cy5.5 dyes and
Gd-DPTA-lipids were incorporated in their polymeric core
and lipid corona, respectively. In vitro studies were
performed to show the protease-induced switching and
utility of this multifunctional nanoparticle platform.
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