Dendrimersomes: a new vesicular nanoplatform for theranostic applications
Miriam Filippi 1 , Marisa Ferraretto 1 , Gilberto Mulas 1 , Jonathan Martinelli 2 , Lorenzo Tei 2 , Mauro Botta 2 , Silvio Aime 1,3 , and Enzo Terreno 1,3
Molecular Biotechnologies and Health
Sciences, University of Turin, Turin, Turin, Italy,
of Sciences and Technological Innovation, University of
Eastern Piedmont 'A. Avogadro', Alessandria, Italy,
for Preclinical Imaging, University of Turin, Colleretto
Giacosa, Turin, Italy
The potential of newly developed nanovesicles, named
dendrimersomes, as MRI reporters was investigated by
encapsulating the contrast agent Gadoteridol inside the
aqueous core or by incorporating a novel dendrimer
covalently conjugated to a Gd-complex into the vesicular
bilayered membrane. Due to the high membrane
permeability, longitudinal relaxivity of encapsulated
probes was subjected only to a limited quenching effect.
On the other hand, membrane-incorporated probes showed
higher relaxivity values that are typical of slowly
rotating Gd-chelates. Stability and imaging studies
suggested that dendrimersomes may have the potential to
act as efficient diagnostic/theranostic MRI agents.
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