Abstract #2966
Investigating Brain Energetics During and After Rat Whole Brain Occlusion
Jennifer M Taylor 1,2 , Xiao-Hong Zhu 2 , Yi Zhang 2 , and Wei Chen 1,2
1
Biomedical Engineering, University of
Minnesota, Minneapolis, MN, United States,
2
Center
for Magnetic Resonance Research, Radiology, University
of Minnesota, Minneapolis, MN, United States
Multi-nuclei
1
H/
31
P
MRS and electrophysiology were applied to investigate
rat brain energetics and neuronal activity changes
during and after whole brain occlusion. PCr change was
consistent among animals, while lactate trends split
into 2 groups. ATP depletion was delayed following
occlusion onset, before following the PCr trend, while
pH and lactate were highly correlated. LFP bands showed
different response dynamics from MRS measures, but
exhibited recovery dynamics similar to ATP. LFP bursts,
however, had a delayed recovery after reperfusion. These
multimodal measures provide insight into the oxidative
to nonoxidative phosphorylation transition and hint at
underlying neuronal energy needs.
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