Abstract #3158
Spin-lock MRI of glucose and deoxyglucose concentration changes in brain
Tao Jin 1 , Hunter Mehrens 1 , and Seong-Gi Kim 1,2
1
Department of Radiology, University of
Pittsburgh, Pittsburgh, Pennsylvania, United States,
2
Center
for Neuroscience Imaging Research, Department of
Biological Sciences, SKKU, Suwon, Korea
With chemical exchange dependent saturation transfer
(CEST) MRI, recent animal studies administering natural
D-glucose demonstrated results comparable to PET, and
showed wide potential applications in diseases such as
cancer. However, this gluco-CEST approach has low
sensitivity, low temporal resolution, and is highly
susceptible to B0 shifts. Furthermore, the CEST signal
is strongly affected by other relaxation effects such as
T1, T2 and magnetization transfer, and lacks a reliable
means to quantify glucose concentration. In this study
we showed that spin-lock MRI is highly sensitive to the
administration of D-glucose and 2-deoxy-D-glucose, and
is able to quantify concentration changes.
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