Real-time motion correction for T1rho mapping of human brain
Ovidiu Cristian Andronesi 1 , Dylan M. Tisdall 1 , and Andre J. van der Kouwe 1
Martinos Center for Biomedical Imaging,
Department of Radiology, Massachusetts General Hospital,
Harvard Medical School, Boston, MA, United States
T1 relaxation in the rotating frame (T1rho) is sensitive
to molecular dynamics of water molecules interacting
with macromolecules and has been shown to be a valuable
imaging biomarker in stroke, neurodegenerative diseases
(Alzheimers Disease, Parkinson Disease), cancer, liver
cirrhosis and cartilage damage. Mapping of T1rho
relaxation constant requires the acquisition of a time
series of images with increasing rotating frame
relaxation weighting. Perfect alignment of the images in
the time series is critical for the accurate fitting of
the T1rho constant. Because of large changes in the
contrast among images acquired at different preparation
(weighting) times, postprocessing motion correction
algorithms have difficulties to accurately coregister
serial volumes and may introduce false displacements.
Here, we show that real-time motion correction improves
the quality of T1rho mapping when subjects move.
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