CEST imaging with phase cycled rectangular RF preparation pulse: analytical solution, simulation and phantom study
Mitsuharu Miyoshi 1 , Tsuyoshi Matsuda 1 , and Hiroyuki Kabasawa 1
Global MR Applications and Workflow, GE
Healthcare Japan, Hino, Tokyo, Japan
Chemical Exchange Saturation Transfer (CEST/APT) is a
new contrast for clinical MRI. Because of SAR and RF
amplifier limitation, continuous RF is not available in
human clinical scanner. Although pulsed RF was used, the
meaning of Z-spectrum is not clear. In this study, novel
CEST preparation pulse with phase cycled 0.232ms
rectangular shaped RF pulse was developed. Z-spectrum
matched well between analytical solution and simulation.
Z-spectrum of phantom was measured with 3T clinical
scanner. B1/SAR was 4.5(ET)/1.0 (W/kg) and less.
Simulation and phantom study show that phase cycled RF
pulse can be used for CEST imaging.
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