Abstract #3300
Selection of irradiation parameters to minimize asymmetric magnetization transfer and NOE contributions in CEST
Tao Jin 1 and Seong-Gi Kim 1,2
1
Department of Radiology, University of
Pittsburgh, Pittsburgh, Pennsylvania, United States,
2
Center
for Neuroscience Imaging Research, Department of
Biological Sciences, SKKU, Suwon, Korea
Magnetization transfer ratio asymmetry (MTR
asym
)
analysis of CEST studies removes direct water saturation
and other symmetric non-CEST contributions. However, in
vivo MTR
asym
is
still confounded by asymmetric contributions, including
magnetization transfer contrast from immobile
macromolecules (MTC
IM
) such as myelin, and
nuclear Overhausser effects (NOE). Compared with the
long-duration, low-power saturation of conventional
CEST, it was recently reported that irradiation of
shorter duration and higher power enhances sensitivity
to amine and hydroxyl protons. In this work we report
that higher irradiation power at shorter duration also
provides another important advantage by minimizing
contributions from MTC
IM
and NOE.
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