Optimal Control in Fast Exchange ParaCEST
Giaime Rancan 1,2 , Thi Thoa Nguyen 1 , Silvio Aime 2,3 , Markus Schwaiger 4 , and Steffen Glaser 1
Technische Universitt Mnchen, Mnchen,
for Advanced Study, Garching, Germany,
degli Studi di Torino, Torino, Italy,
rechts der Isar, Mnchen, Germany
Optimal control algorithms can provide the perfect
framework for a facile and flexible tailoring of pulses
to experimental conditions in well characterized two or
three pool exchange systems. A CEST contrast agent of
clinical interest, YbHPDO3A, is considered for
presaturation pulse optimization, revealing the
non-optimality of standard continuous wave irradiation
under the considered energy limitations.
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