Abstract #3316
Interpretation of conventional APT contrast in tumor and ischemic tissue
Zhongliang Zu 1 , Hua Li 1 , Junzhong Xu 1 , Daniel F Gochberg 1 , and John C Gore 1
1
Vanderbilt University, Nashville, TN, United
States
APT provides a potential method for detecting changes in
mobile proteins/peptides or pH, and has been applied to
several pathologies including tumor and stroke. However,
the in vivo contrast seen is complex and not fully
understood. Here, we interpret the conventional APT
contrast in tumor and postmortem tissues via experiments
and simulations. We found that conventional APT contrast
from asymmetry analyses of both tumor and ischemia CEST
data at lower fields (e.g. 4.7T) is derived mostly from
amine especially at high irradiation power, whereas
contrast from tumors at high field (e.g. 9.4T) comes
mostly from the MT asymmetry and NOEs.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
