Impact of inversion-recovery fat suppression on hepatic R2* quantitation in transfusional siderosis.
Antonella Meloni 1,2 , J. Michael Tyszka 3 , Alessia Pepe 1 , Massimo Lombardi 1 , and John C Wood 2,4
CMR Unit, Fondazione G.Monasterio
CNR-Regione Toscana and Institute of Clinical
Physiology, Pisa, Italy,
of Pediatrics, Division of Cardiology, Childrens
Hospital Los Angeles, Los Angeles, California, United
of Biology, California Institute of Technology,
Pasadena, California, United States,
of Radiology, Childrens Hospital Los Angeles, Los
Angeles, California, United States
This represents the first study to compare the impact of
fat saturation prepulse on R2* quantitation in
transfusional siderosis. We demonstrate that SPIR fat
suppression systematically lowered R2* estimates by 3.9%
7.0, and introduced comparable random uncertainty
between the two measurements. Since calibration curves
have been derived using non-fat saturated images, these
biases should be corrected when reporting LIC values
from fat saturated images.
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