Abstract #3588
Fat Quantification in Chronic Liver Disease Patients with 3D Multi-Echo GRE Dixon at 1.5 T: Comparison with T2 Corrected Spectroscopy
Liana Guerra Sanches-Rocha 1 , Ludmila Ribeiro 1 , Karine Minaif Martins 2 , Ralph Markus Strecker 3 , Xiadong Zhong 4 , Stephan Kannengiesser 5 , and Ronaldo Hueb Baroni 2
1
Imaging, Albert Einstein Hospital, So
Paulo, So Paulo, Brazil,
2
Imaging,
Albert Einstein Hospital, So Paulo, Brazil,
3
Siemens
Ltda, So Paulo, Brazil,
4
MR
R&D Collaborations, Siemens Healthcare MR R&D
Collaborations, Georgia, United States,
5
MR
R&D Collaborations, Siemens Medical Solutions, Germany
The fat fraction measure using magnetic resonance
imaging has been highly accurate alternative method to
the biopsy procedure. The spectroscopy has been used as
accurated methodology to access and monitor liver
steatosis. The method had some of it's problem solved
with the T2 correction in a fast aquisition (HISTO). In
this study, we aimed to validate against the HISTO
spectroscopy, a new 6-echoes-gradient-echo sequence,
that uses a hybrid magnitude/complex data algorithm,
including correction for T1 bias and T2* decay, and
multipeak fat spectrum, that already has been validated
at 3T system, at a clinical wide -bore 1,5T system. We
evaluated 69 sets from patients that are waiting for
liver transplantation and had undergone abdominal MRI.
The fat percentage result from inline HISTO report and
the proton density fat fraction (PDFF) obtained from the
map generate inline from the new sequence were
correlated. The intraclass correlation coefficient (ICC)
between both sequenceswas 0,830 (CI95%=0,737 to 0,891)
for fat percentage . We conclued that the new sequence,
with multipeak fat spectral modeling and six-echo
chemical shift encoding, has a good correlation with
HISTO spectroscopy in the PDFF for chronic liver disease
patients at 1,5T.
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