Quantitative Perfusion with Hyperpolarized 13C-tert-butanol: Correlation against ASL and Quantitative Immunohistopathology
Leo L Tsai 1 , Xiaoen Wang 1 , Gopal Varma 1 , Benjamin Edelstein 1 , Rupal Bhatt 2 , David C Alsop 1 , and Aaron K Grant 1
Department of Radiology, Beth Israel
Deaconess Medical Center, Boston, MA, United States,
of Medicine, Beth Israel Deaconess Medical Center,
Boston, MA, United States
Hyperpolarized C-13-tert-butanol (hC13-tert-butanol)
provides a robust and rapid method of tumor perfusion
quantification with high SNR, with high translational
potential for clinical monitoring of antiangiogenics.
Here we show excellent correlation of hC13-tert-butanol
perfusion quantification as compared to ASL and direct
immunostaining with CD34.
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