Abstract #3800
Purely endogenous hyperpolarized [1-13C]Pyruvate solutions for metabolic study in glioblastoma rat models
Mor Mishkovsky 1,2 , Emine Can 3 , Tim Eichhorn 4 , Denis Mario 5 , Ivan Radovanovic 5 , Rolf Gruetter 1,6 , Virginie Clment-Schatlo 5 , and Arnaud Comment 3
1
Laboratory for Functional and Metabolic
Imaging (LIFMET), Ecole Polytechnique Fdrale de
Lausanne (EPFL), Lausanne, Switzerland,
2
Department
of radiology, Univesity of Lausanne, Lausanne,
Switzerland,
3
Institute
of Physics of Biological Systems, Ecole Polytechnique
Fdrale de Lausanne (EPFL), Lausanne, Switzerland,
4
Paul
Scherrer Institute (PSI), Villigen, Switzerland,
5
Hpitaux
Universitaires de Genve (HUG), Geneva, Switzerland,
6
Department
of radiology, Univesity of Lausanne and Geneva,
Switzerland
Hyperpolarized [1-13C]pyruvate solutions prepared
without persistent radicals were used to study brain
metabolism in rat model of human glioblastoma. Real time
in vivo pyruvate metabolism was acquired with large
signal-to-noise ratio that allows studying the kinetic
of the LDH-mediated conversion of pyruvate to lactate in
the tumor. The use of completely endogenous sample
compositions through all the steps of the dissolution
DNP experiment can facilitate the clinical application
of hyperpolarized pyruvate for tumor diagnostic and
treatment response as the filtration step is eliminated.
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