Contrast agents with chelated lanthanoid ions for 19F MR imaging
Vt Herynek 1 , Marie Martiniskov 2 , Andrea Glisov 1 , Jan Kotek 2 , Daniel Jirk 1 , and Milan Hjek 1
Institute for Clinical and Experimental
Medicine, Prague, Czech Republic,
of Science, Charles University, Prague, Czech Republic
19F MRI is potentially an interesting tool for diffusion
or perfusion measurements, and for cell tracking. It
requires biocompatible and non-toxic contrast agents
with high fluorine ion concentration with suitable
relaxation times. We synthesized and tested both in
vitro and in vivo probes based on DOTP chelates with 12
equivalent fluorine ions and a lanthanoid ion, which
substantially shortens relaxation times. Measuring
sequences were optimized for each chelated lanthanoid.
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