Comparison of 3T and 14T MRI in a rat antigen-induced arthritis model.
Lindsey Alexandra Crowe 1 , Nicolas Kunz 2 , Iris Friedli 1 , Azza Gramoun 1 , Kerstin Grosdemange 1 , Lionel Maurizi 3 , Geraldine Coullerez 3 , Marie-Gabrielle Beuzelin 3 , Rolf Gruetter 2 , Heinrich Hofmann 3 , and Jean-Paul Valle 1
Radiology, Geneva University Hospitals,
of Functional and Metabolic Imaging, Ecole Polytechnique
Fdrale de Lausanne, Lausanne, Switzerland,
Technology Laboratory, Ecole Polytechnique Fdrale de
Lausanne, Lausanne, Switzerland
The use of iron oxide nanoparticles in MRI is leading
development of image acquisition and analysis techniques
to accurately localize uptake and persistence of such
contrast agents. Detailed localization of the SPION and
its contrast to other structures that are also
hypointense is important. We explore the advantages of
high field and high resolution MRI to assess
inflammation, macrophage uptake and bone erosion in an
antigen-induced arthritis (AIA) model.
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